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CAS 393-52-2

2-Fluorobenzoyl Chloride

Benzoyl Chlorides Pharma Agro


2-Fluorobenzoyl chloride is a colorless transparent liquid, an important fluorinated aromatic acyl chloride intermediate widely used in pharmaceuticals, pesticides, and fine chemicals. It has a melting point of 4℃, a boiling point of 95℃ (20 mmHg), hydrolyzes vigorously on contact with water, and requires sealed storage.

The distinctive feature of 2-fluorobenzoyl chloride lies in the dual role of the ortho fluorine: the strong electron-withdrawing effect of fluorine enhances the electrophilic reactivity of the acyl chloride, making acylation efficient, while the steric bulk of the ortho fluorine moderately buffers the reaction rate, reducing side reactions. This combination of “reactivity with controllability” makes it a preferred reagent for fluorinated acylation of substrates bearing sensitive groups, and the fluorine label also confers good metabolic stability on the product.



Applications: Intermediate for fluorinated antipsychotic, anti-inflammatory and cardiovascular drugs; fluorinated herbicides, insecticides and liquid crystal display materials.

 

Appearance

Colorless transparent liquid

Melting Point

4 °C

Boiling Point

95 °C / 20 mmHg

Molecular Formula

C7H4ClFO

Molecular Weight

158.56 g/mol

Purity

≥ 99%

Packaging

250 kg drum

COA

Available on request


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Taixing Zhongran Chemical Co., Ltd. founded in 2001, is a professional manufacturer of pharmaceutical, agrochemical and dye intermediates. 2-Fluorobenzoyl Chloride Factory. Located in Taixing Economic Development Zone, Jiangsu Province, China.
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